- Hubert PIERLOT (26/09/1944 – 7/02/1945)
- Achille VAN ACKER I (12/02/1945 – 15/06/1945)
- Achille VAN ACKER II (2/08/1945 – 12/02/1946)
- Paul-Henri SPAAK I (13/03/1946 – 20/03/1946)
- Achille VAN ACKER III (31/03/1946 – 9/07/1946)
- Camille HUYSMANS (3/08/1946 – 13/03/1947)
- Paul-Henri SPAAK II (20/03/1947 – 19/11/1948)
- Paul-Henri SPAAK III (27/11/1948 – 27/06/1949)
- Gaston EYSKENS I (11/08/1949 – 6/06/1950)
- Jean DUVIEUSART (8/06/1950 – 11/08/1950)
- Joseph PHOLIEN (16/08/1950 – 9/01/1952)
- Jean VAN HOUTTE (15/01/1952 – 12/04/1954)
- Achille VAN ACKER IV (23/04/1954 – 2/06/1958)
- Gaston EYSKENS II (26/06/1958 – 4/11/1958)
- Gaston EYSKENS III (6/11/1958 – 3/09/1960)
- Gaston EYSKENS III (remanié) (3/09/1960 – 27/03/1961)
- Théo LEFEVRE (25/04/1961 – 24/05/1965)
- Pierre HARMEL (28/07/1965 – 11/02/1966)
- Paul VANDEN BOEYNANTS I (19/03/1966 – 1/04/1968)
- Gaston EYSKENS IV (17/06/1968 – 8/11/1971)
- Gaston EYSKENS V (21/01/1972 – 23/11/1972)
- Edmond LEBURTON I (26/01/1973 – 23/10/1973)
- Edmond LEBURTON II (23/10/1973 – 19/01/1974)
- Léo TINDEMANS I (25/04/1974 – 11/06/1974)
- Léo TINDEMANS II (11/06/1974 – 4/03/1977)
- Léo TINDEMANS III (6/03/1977 – 18/04/1977)
- Léo TINDEMANS IV (3/06/1977 – 11/10/1978)
- Paul VANDEN BOEYNANTS II (20/10/1978 – 18/12/1978)
- Wilfried MARTENS I (3/04/1979 – 16/01/1980)
- Wilfried MARTENS II (23/01/1980 – 9/04/1980)
- Wilfried MARTENS III (18/05/1980 – 7/10/1980)
- Wilfried MARTENS IV (22/10/1980 – 2/04/1981)
- Mark EYSKENS (6/04/1981 – 21/09/1981)
- Wilfried MARTENS V (17/12/1981 – 14/10/1985)
- Wilfried MARTENS VI (28/11/1985 – 15/10/1987)
- Wilfried MARTENS VII (21/10/1987 – 13/12/1987)
- Wilfried MARTENS VIII (9/05/1988 – 29/09/1991)
- Wilfried MARTENS IX (29/09/1991 – 25/11/1991)
- Jean-Luc DEHAENE I (7/03/1992 – 22/05/1995)
- Jean-Luc DEHAENE II (23/06/1995 – 14/06/1999)
- Guy VERHOFSTADT I (12/07/1999 – 19/05/2003)
- Guy VERHOFSTADT II (12/07/2003 – 11/06/2007)
- Guy VERHOFSTADT III (21/12/2007 – 20/03/2008)
- Yves LETERME I (20/03/2008 – 19/12/2008)
- Herman VAN ROMPUY (30/12/2008 – 25/11/2009)
- Yves LETERME II (25/11/2009 – 26/04/2010)
- Elio DI RUPO (05/12/2011 – 26/05/2014)
- Charles MICHEL I (11/10/2014 – 09/12/2018)
- Charles MICHEL II (09/12/2018 – 21/12/2018)
- Sophie WILMES I (27/10/2019 – 27/10/2019)
- Sophie WILMES II (17/03/2020 – 01/10/2020)
- Alexander DE CROO (01/10/2020 – )